The Team Created a Circular Single-stranded DNA Containing Sequences to Bind miR-92018.05.29
As a biological medicine with strong targeting and relatively clear functions, MicroRNA is also an important field for drug development. The team led by Prof. Cheng Yang, Nankai University, made a new progress on the study of the related research. With Jing Meng, doctor (graduated in 2017) of Nankai University’s College of Pharmacy as its first author, the paper has been published on Science Translational Medicine on May 23rd. Nankai University’s College of Pharmacy, State Key Laboratory of Medicinal Chemical Biology, and Tianjin International Joint Academy of Biomedicine all contributed to the work.
The group found that cancer patients with low tumor expression of the tumor suppressor genes KLF17, CDH1, and LASS2 had shortened survival times. Circular single-stranded DNA (CSSD) can up-regulate the expression of co-silenced tumor suppressor genes by sequestering microRNAs (miRNAs) that negatively regulate these genes. Thus, through this strategy, the tumor progression and pulmonary metastasis can be suppressed, and transfecting CSSDs via nanoparticles substantially improved delivery efficiency.The results of current cell and animal model studies show that the suppression works well in the tumors of liver cancer, breast cancer, lung cancer, ovarian cancer and cervical cancer whose amount of miRNA-9 is high. Comparing to present miRNA suppressors, CSSD is more stable and effective and much safer, so it has a high value of development.
Professor Cheng Yang’s research team is mainly engaged in the drug development and pharmacological research on tumors, organ fibrosis and metabolic diseases. The research team has obtained a number of invention patents and two clinical approvals, one of which entered Clinical Phase I.
Link to the paper for more details: http://stm.sciencemag.org/content/10/442/eaao6321
Source: Nankai News
Written by Yuntao Sun
Edited by Yuchen Shi and Ruoyan Yan