Research Progress: Co-assembly of Cyclodextrin and Calixarene Amphiphiles Provides New Strategy in Resisting Alzheimer 2018.12.02

Fig. 1: Illustration of the heteromultivalent peptide recognition by co-assembly of CD and CA amphiphiles

Recently, the research team led by Prof. Dongsheng Guo, Nankai University, in collaboration with Prof. Bart Jan Ravoo, University of Münster (Germany) has made breakthrough in enabling the inhibition of amyloid fibrillation by co-assembled heteromultivalent recognition, providing new supramolecular strategy for prevention and treatment of neurogenic diseases such as Alzheimer. The research finding has been published on Nature Chemistry (DOI:10.1038/s41557-018-0164-y). Prof. Dongsheng Guo and Prof. Bart Jan Ravoo serve as co-corresponding authors.

Alzheimer, Parkinson, etc. are neurodegenerative diseases, which seriously affect the quality of life of patients, and bring heavy mental and economic burdens to patients, families and society. According to China Pharmaceutical Pipeline Monitor (CPM), there have been 1,141 developing drugs in the world since the last century. However, with 68.4% in no progress or termination, only 15 drugs have come into the market. Among them, only 6 have received the approval by the US Food and Drug Administration, and the other 9, confined to designated regions. On November 6th, President Xi Jinping learnt about the research and development of therapeutic drugs for Alzheimer’s disease and pointed out the necessity to establish independent research and development during his visit to Shanghai Scientific and Technological Innovation Center and national science and technology highland.

“As a conceptual confirmation, the research has potential application value in prevention and treatment of Alzheimer’s disease. But we still have a long way to go for the application in Alzheimer’s disease in reality. You could even say it is rather difficult,” said Prof. Dongsheng Guo. Guo claimed that the team would persist in the research for improving the system progressively.

Fig. 2: Heteromultivalent peptide recognition by co-assembly of CD and CA amphiphiles enables inhibition of amyloid fibrillation

Source: Nankai News

Written by Chao Ma

Edited by Ruoyan Yan and Yuchen Shi


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