NKU Team Developed An In Vitro Protective Coating for Preparation and Storage of Biopharmaceuticals 2018.12.03

In science fiction films, the mysterious biological antibodies or biochemical drugs, is usually stored in green or blue liquid in tubular glass containers or in various portable refrigerators. This reflects the fact that biological agents such as antibody drugs are highly susceptible to external environments such as temperature, pH, and pressure. Therefore, cold chain treatment or addition of stabilizers is required during their transportation and use, which may lead to an increase in production costs and potential safety hazards to some extent. Recently, a research team of Nankai University provided a new strategy for solving this problem.

The team led by researcher Chen Yao, State Key Laboratory of Medicinal Chemistry Biology and College of Pharmacy of Nankai University, used one-step method to combine antibody molecules with metal salts and organic ligands under a mild synthesis condition and synthesized a new type of “molecular armor” (antibodies@MOFs). The new coating provides good thermal, chemical and mechanical protection for antibodies, extending the life spans of antibodies and allowing their protective layers to be quickly removed under mild conditions. Experiments revealed that antibodies that wear "molecular armor" can be stored, transported and used for long-term in daily or extreme environments.

On November 27th, a thesis introducing the achievement was published online in the Advanced Materials, an authoritative journal in the field of international material chemistry. The paper has also been selected as the latest cover article.

Yifan Feng, doctoral student in Chen Yao’s team of Nankai University, is the first author of the thesis, and Wang Huanrong, master student, is the second author. Yao Chen and Shengqian Ma, professor with the University of South Florida, are co-corresponding authors. The research was supported by the National Laboratory of Medicinal Chemistry Biology, the College of Pharmacy, the National Natural Science Foundation of China, and the Tianjin Natural Science Foundation.

Link to: https://onlinelibrary.wiley.com/doi/full/10.1002/adma.201805148

News background:

Metal-Organic Frameworks (MOFs) are a new class of porous materials that have developed rapidly in the past two decades and belong to the most popular field of organic-inorganic composites. Compared to conventional porous materials, metal-organic framework materials have greater void fraction and specific surface area, especially adjustable pore size and variable functional groups. Currently, metal-organic framework materials have been used in hydrogen storage, drug delivery, catalytic reactions, biosensors, gas adsorption and separation. The research on metal-organic framework materials involves the latest achievements in the fields of organic chemistry, inorganic chemistry, coordination chemistry, materials chemistry, life sciences and computer science. Therefore, metal-organic framework materials have attracted the attention of more and more research teams in recent years.

Source: Nankai News

Written by Junhui Wu

Edited by Kuqing Li and Ruoyan Yan

Nankai University

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